ANAPLASTIC THYROID CANCER: GENETIC ROLES, TARGETED THERAPY, AND IMMUNOTHERAPY


A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Abstract Telomeres prevent ATM activation by Mechanical Safety Switch sequestering chromosome termini within telomere loops (t-loops).Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.Using unbiased interactomics, biochemical screening, molecular biology, and sup

read more